This study evaluates the applicability of the CAMELS classification and related financial determinants for banks across countries. By analyzing 181 banks from North America, Oceania, Europe, and major Asian countries, using data from Bloomberg for the period 2006-2013, we aim to understand the global impact of financial shocks. Using financial distress dummy as the dependent variable and CAMELS variables as explanatory factors, our panel probit regressions reveal significant variations in how these financial variables react across different regions. The findings suggest that a one-size-fits-all global approach may be insufficient due to business cultural differences and legal frameworks that affect bank management and default risks. Thus, effective bank supervision requires tailored approaches at the country or regional level, while global regulatory institutions should strive for enhanced security and transparency in the banking sector.